Therapeutic Ultrasound

1.         Feril LB Jr, Kondo T, Zhao QL, Ogawa R. Enhancement of hyperthermia-induced apoptosis by non-thermal effects of ultrasound. Cancer Letters 2002; 178:63-70.  Ferilink

2.         Feril LB Jr, Kondo T, Umemura S, Tachibana K, Manalo AH, Riesz P. Sound waves and antineoplastic drugs: the possibility of an enhanced combined anticancer therapy. Journal of Medical Ultrasonics 2002; 29:173-87. Ferilink 

3.         Feril LB Jr, Kondo T, Ogawa R, Zhao QL. Dose-dependent inhibition of ultrasound-induced cell killing and free radical production by carbon dioxide. Ultrasonics Sonochemistry 2003; 10:81-4. Ferilink 

4.         Feril LB Jr, Kondo T, Zhao QL, Ogawa R, Tachibana K, Kudo N, Fujimoto S, Nakamura S. Enhancement of ultrasound-induced apoptosis and cell lysis by echo-contrast agents. Ultrasound in Medicine and Biology 2003; 29:331-7. Ferilink 

5.         Feril LB Jr, Kondo T, Takaya K, Riesz P. Enhanced ultrasound-induced apoptosis and cell lysis by a hypotonic medium. International Journal Radiation Biology, 2004; 80, 165-175.  Ferilink

6.         Feril LB Jr, Tsuda Y, Kondo T, Zhao QL, Ogawa R, Cui ZG, Tsukada K, Riesz P. Ultrasound-induced killing of monocytic U937 cells enhanced by 2,2'azobis (2-amidinopropane) dihydrochloride. Cancer Science 2004; 95, 181-5.  Ferilink 

7.         Feril LB Jr, Kondo T. Major factors involved in the inhibition of ultrasound-induced free radical production and cell killing by pre-sonication incubations and by high cell density. Ultrasonics Sonochemistry 2005; 12, 353-357F. Ferilink 

8.         Feril LB Jr, Ogawa R, Kobayashi H, Kikuchi H, Kondo T. Ultrasound enhances liposome-mediated gene transfection. Ultrasonics Sonochemistry 2005; 12:489-493. Ferilink 

9. Feril LB Jr., Kondo T, Cui Z-G, Tabuchi Y, Zhao Q-L, Hidetaka A, Misaki T, Yoshikawa H, Umemura S, Apoptosis induced by the sonomechanical effects of low intensity pulsed ultrasound in a human leukemia cell line. Cancer Letters 2005; 221:145-152 Ferilink

10.     Feril LB Jr, Kondo T. Biological effects of low intensity ultrasound: the mechanism involved, and its implications on therapy and on biosafety of ultrasound. Journal of Radiation Research 2004; 45, 479-489. Ferilink

11.     Feril, L.B. Jr., Kondo, T Ultrasound liberates nitric oxide (NO) from the caged NO compound N,N'-bis(carboxymethyl)-N,N�f-dinitroso-p-phenylenediamine sodium salt. Ultrason. Sonochem. 2006, 13:397-400. Ferilink

12.     Li FJ, Kondo T, Zhao QL, Hayashi Y, Ogawa R, Cui ZG, Feril LB Jr. A lipophilic free radical initiator, 2,2�f-azobis (2,4-dimethylvaleronitrile) (AMVN) enhances caspase-dependent apoptosis induced by hyperthermia. International Journal of Hyperthermia 2003; 19:165-77. Ferilink

13.     Nozaki T, Ogawa R, Feril LB Jr, Kagiya G, Fuse H, Kondo T. Enhancement of ultrasound-mediated gene transfection by membrane modification. J Gene Med 2003; 5:1046-55. Ferilink 

14.     Cui ZG, Kondo T, Ogawa R, Feril LB Jr. Zhao QL, Wada S, Arai T, Makino K. Enhancement of radiation-induced apoptosis by 6-formylpterin. Free Radical Research, 2004; 38, 363-373. Ferilink

15.     Honda H, Kondo T, Zhao QL, Feril LB Jr, Kitagawa H. Role of intracellular calcium ions and reactive oxygen species in apoptosis induced by ultrasound. Ultrasound Med Biol 2004, 30:683-92. Ferilink

16.     Hayashi Y, Kondo T, Zhao QL, Ogawa R, Cui ZG, Feril LB Jr, Teranishi H, Kasuya M. Signal transduction of p53-independent apoptotic pathway induced by hexavalent chromium in U937 cells. Toxicology and Applied Pharmacology, 2004; 197: 96-106. Ferilink 

17.     Ogawa R, Kagiya G, Feril LB Jr, Nakaya N, Nozaki T, Fuse H, Kondo T. Ultrasound mediated intravesical transfection enhanced by treatment with lidocaine or heat. J Urology, 2004, 172: 1469-1473. Ferilink

18. Cui Z-G, Kondo T, Feril LB Jr, Waki K, Inanami O, Kuwabara M. Effects of antioxidants on X-ray- or hyperthermia-induced apoptosis in human lymphoma U937 cells. Apoptosis 2004, 9:757-763. Ferilink

19. Hirano H, Tabuchi Y, Kondo T, Zhao Q-L, Ogawa R, Cui Z-G, Feril LB Jr, Kanayama S. Analysis of gene expression in apoptosis of human lymphoma U937 cells induced by heat shock and the effects of PNB and its derivatives. Apoptosis 2004, 10:331-40. Ferilink

20. Kagiya G, Ogawa R, Tabuchi Y, Feril LB Jr, Nozaki T, Fukuda S, Yamamoto K, Kondo T. Expression of heme oxygenase-1 due to intracellular reactive oxygen species induced by ultrasound. Ultrason. Sonochem. 2006, 13:388-96. Ferilink

21. Kagiya G, Tabuchi Y, Feril LB Jr, Ogawa R, Zhao Q-L, Kudo N, Hiraoka W, Tachibana K, Umemura S, Kondo T. Confirmation of enhanced expression of heme oxygenase-1 gene induced by ultrasound and its mechanism: analysis by cDNA microarray system, real-time quantitative PCR, and western blotting. J Med Ultrasonics 2006, 33:3-10. Ferilink

22. Hiraoka W, Honda H, Feril LB Jr, Kudo N, Kondo T. Comparison between sonodynamic effect and photodynamic effect with photosensitizers on free radical formation and cell killing Ultrason. Sonochem.2006, 13:535-42 Ferilink

23. Ando H., Feril LB Jr, Kondo T, Tabuchi Y, Ogawa R, Zhao QL, Cui ZG, Umemura S, Yoshikawa H, Misaki T. A echo-contrast agent, Levovist, lowers the ultrasound intensity required to induce apoptosis of human leukemia cells. Cancer Lett. 2006, 242:37-45. Ferilink

24. Cheng C, Tsuneyama K, Zheng H, Oya T, Cui Z, Feril LB Jr, Takano Y. Enhanced scavenging of lipid substances is a possible effect of corticosteroids in the treatment of cholesterol crystal embolism. Pathol Res Pract. 2006, 202:591-8. Ferilink

25.     Feril LB Jr, Ogawa R, Tachibana K and Kondo T. Optimized ultrasound-mediated gene transfection in cancer cells. Cancer Science 2006, 97:1111-4. Ferilink

26.     Tabuchi Y, Ando H, Takasaki I, Feril LB Jr, Zhao Q-L, Ogawa R, Kudo N, Tachibana K, and Kondo T. Identification of genes responsive to low intensity pulsed ultrasound in a human leukemia cell line Molt-4. Cancer Lett 2007 (Feb) 246 (1-2): 149-56. Ferilink

27.     Yoshida T, Kondo T, Ogawa R, Feril LB Jr, Zhao QL, Watanabe A, Tsukada K. Combination of doxorubicin and low-intensity ultrasound causes a synergistic enhancement in cell killing and an additive enhancement in apoptosis induction in human lymphoma U937 cells Cancer Chemother Pharmacol 2008, 61(4):559-67. Ferilink

 28. Feril LB Jr, Kondo T, Tabuchi Y, Ogawa R, Zhao Q-L, Nozaki T, Yoshida T, Kudo K, and Tachibana K. Biomolecular effects of low intensity ultrasound: apoptosis, sonotransfection and gene expression�@Japanese Journal of Applied Physics 2007, 46 (7B): 4432-40. Ferilink

29. Salunga TL, Tabuchi Y, Takasaki I, Feril LB Jr., Zhao Q-L, Ohtsuka K, Tsuneyama K and Kondo T. Identification of genes responsive to paeoniflorin, a heat shock protein-inducing compound, in human leukemia U937 cells. International Journal of Hyperthermia 2007, 23(6):529-37

30. Danno D, Kanno M, Fujimoto S, Feril LB Jr, Kondo T and Nakamura S. Effects of ultrasound on apoptosis induced by anti-CD20 antibody in CD20-positive B lymphoma cells. Ultrasonics Sonochemistry 2007, 15(4):463-71

31. Ahmed K, Zhao Q-L, Matsuya Y, Yu DY, Feril LB Jr, Nemotot H, Kondo T. Rapid and transient intracellular oxidative stress due to novel macrosphelides trigger apoptosis via Fas/caspase-8-dependent pathway in human lymphoma U937 cells. Chem Biol Interact. 2007, 170(2):86-9..Ferilink

32. Tachibana K, Feril LB Jr, Ikeda-Dantsuji Y..Sonodynamic therapy. Ultrasonics. 2008 (In press) Ferilink

33. Tabuchi Y, Takasaki I, Zhao QL, Wada S, Hori T, Feril LB Jr, Tachibana K, Nomura T, Kondo T. Genetic networks responsive to low-intensity pulsed ultrasound in human lymphoma U937 cells. Cancer Lett 2008 (In press) Ferilink

34. Ogawa R, Lee S, Izumi H, Kagiya G, Yoshida T, Watanabe A, Morii A, Kakutani S, Kondo T, Feril LB Jr, Ishimoto T. Enhancement of artificial promoter activity by ultrasound-induced oxidative stress. Utrason Sonochem 2008 (In press)

35. Hassan MA, Feril LB Jr, Suzuki K, Kudo N, Tachibana K, Kondo T. Evaluation and comparison of three novel microbubbles: Enhancement of ultrasound-induced cell death and free radicals production. Ultrasonics Sonochmistry 2008 (In press)

36. Feril LB Jr, Tachibana K, Ogawa K, Yamaguchi K, Solano I, Irie Y. Therapeutic potential of low-intensity ultrasound (part 1): thermal and sonodynamic effects. J. Medical Ultrasonics 2008 35: 153-60

37. Feril LB Jr, Tachibana K, Ikeda-Dantsuji Y, Endo H, Harada Y, Kondo T, Ogawa R. Therapeutic potential of low-intensity ultrasound (part 2): biomolecular effects, sonotransfection, and sonoporation. J. Medical Ultrasonics 2008 35: 161-67.

38. Yamaguchi K, Feril LB Jr, Harada Y, Endo H, Irie Y, Nakayama J, Tachibana K. Growth inhibition of neurofibroma by ultrasound-mediated interferon gamma transfection J. Medical Ultrasonics 2009 36: 3-8..

39. Buldakov MA, Hassan MA, Zhao Q-L, Feril LB Jr, Kudo N, Kondo T, Litvyakov NV, Bolshakov MA, Rostov VV, Cherdyntseva NV, Riesz P. Influence of Changing Pulse Repetition Frequency on Chemical and Biological Effects Induced by Low Intensity Ultrasound In-vitro. Ultrasonics Sonochmistry 2009 16: 392-7..

40. Watanabe A, Kakutani S, Ogawa R, Lee S, Yoshida T, Morii A, Kagiya G, Feril LB Jr, Fuse H, Kondo T. Construction of artificial promoters sensitively responsive to sonication in vitro. J. Medical Ultrasonics 2009 36(1): 9-17. 

41. Kondo T, Yoshida T, Ogawa R, Hasaan MA, Furusawa Y, Zhao QL, Watanabe A, Morii A, Feril LB Jr, Tachibana K, Kitagawa H, Tabuchi Y, Takasaki I, Shehata MH, Kudo N, Tsukada K. Low-intensity ultrasound adjuvant therapy: The enhancement of doxorubicin-induced cytotoxicity and the acoustic mechanisms involved. J Medical Ultrasonics  2009 36: 61-68.

42. Feril LB Jr, Tachibana K, Kondo T, Ogawa R, Zhao QL, Yamaguchi K, Ogawa K, Endo H, Irie Y, Harada Y. Hypotonia-induced cell swelling enhances ultrasound-induced mechanical damage on cancer cells. J Medical Ultrasonics 2010 37: 3-8.

1.     Feril LB Jr, Kondo T. Biological effects of low intensity ultrasound: A sound idea potentially useful for therapy. Toyama Medical Journal 2004; 15:66-71.

2.     Kondo T, Li FJ, Zhao QL, Cui ZG, Ogawa R, Feril LB Jr, Hayashi Y. Enhancement of hyperthermia-induced apoptosis by free radical generators. Jpn J Cancer Clin 2002; 48:270-3. (In Japanese)

3.     Ogawa R, Nozaki T, Feril LB Jr, Kagiya G, Fuse H, Kondo T. Current status of gene therapy research using ultrasound. Radiation Biology Research Communications 2003; 38: 271-285. (In Japanese)

4.     Kondo T, Zhao Q-L, Cui Z-G, Feril LB Jr, Ogawa R, Fujiwara Y, Honda H, Tsuda Y, Wada S, Yuki H, Arai T, Makino K. Enhancement of radiation- and hyperthermia-induced apoptosis by excess oxidative stress. Jpn J Cancer Clin 2003; 49:13-6. (In Japanese)

5.     Cui ZG, Wada S, Kondo T, Fujiwara Y, Zhao QL, Ogawa R, Nagaki Y, Shoji M, Tabuchi Y, Yuki H, Feril LB Jr. Enhancement of hyperthermia-induced apoptosis by modification of intracellular oxidative stress. Jpn. J. Hyperthermic Oncol. 2005, 21: 71-80

6.     Feril LB Jr, Tachibana K. Ultrasound in medicine: To search and destroy diseased tissues. Philippine Physics J. 2006, 28, 67-72

7.     Tachibana K, Feril LB Jr. Using ultrasound for drug delivery. Philippine Physics J. 2006, 28, 125-135

8. Feril LB Jr, Tachibana K, Yamaguchi K, Ogawa K, Ikeda-Dantsuji Y, Irie Y, Endo H. Bioeffects of ultrasound for therapy. Philippine Physics J. 2007, 29:1-4

9. Buldakov MA, Feril LB Jr. Dual role of low-dose ionizing radiation. Philippine Physics J. 2008, B 30:1-8

10. Moreno DC, Feril LB Jr, Tachibana K, Irie Y. Gene transfection through microbubble-aided sonication in cancer cells. Philippine Physics J.  2009, 31: 1-7.